Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells.
Identifieur interne : 002046 ( Main/Exploration ); précédent : 002045; suivant : 002047Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells.
Auteurs : Xinrong Tao [États-Unis] ; Terence E. Hill ; Chikao Morimoto ; Clarence J. Peters ; Thomas G. Ksiazek ; Chien-Te K. TsengSource :
- Journal of virology [ 1098-5514 ] ; 2013.
Descripteurs français
- KwdFr :
- Apoptose, Bronches (anatomopathologie), Bronches (virologie), Cellules épithéliales (anatomopathologie), Cellules épithéliales (virologie), Coronavirus (pathogénicité), Coronavirus (physiologie), Effet cytopathogène viral (physiologie), Humains, Libération de particules virales (physiologie), Lignée cellulaire, Polarité de la cellule, Pénétration virale, Spécificité d'espèce, Virus du SRAS (pathogénicité), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Bronches, Cellules épithéliales.
- pathogénicité : Coronavirus, Virus du SRAS.
- physiologie : Coronavirus, Effet cytopathogène viral, Libération de particules virales, Virus du SRAS.
- virologie : Bronches, Cellules épithéliales.
- Apoptose, Humains, Lignée cellulaire, Polarité de la cellule, Pénétration virale, Spécificité d'espèce.
English descriptors
- KwdEn :
- Apoptosis, Bronchi (pathology), Bronchi (virology), Cell Line, Cell Polarity, Coronavirus (pathogenicity), Coronavirus (physiology), Cytopathogenic Effect, Viral (physiology), Epithelial Cells (pathology), Epithelial Cells (virology), Humans, SARS Virus (pathogenicity), SARS Virus (physiology), Species Specificity, Virus Internalization, Virus Release (physiology).
- MESH :
- pathogenicity : Coronavirus, SARS Virus.
- pathology : Bronchi, Epithelial Cells.
- physiology : Coronavirus, Cytopathogenic Effect, Viral, SARS Virus, Virus Release.
- virology : Bronchi, Epithelial Cells.
- Apoptosis, Cell Line, Cell Polarity, Humans, Species Specificity, Virus Internalization.
Abstract
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.
DOI: 10.1128/JVI.01562-13
PubMed: 23824802
Affiliations:
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Le document en format XML
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Hill</name></author><author><name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name></author><author><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J" last="Peters">Clarence J. Peters</name></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G" last="Ksiazek">Thomas G. Ksiazek</name></author><author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K" last="Tseng">Chien-Te K. 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Hill</name></author><author><name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name></author><author><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J" last="Peters">Clarence J. Peters</name></author><author><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G" last="Ksiazek">Thomas G. Ksiazek</name></author><author><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K" last="Tseng">Chien-Te K. Tseng</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis</term><term>Bronchi (pathology)</term><term>Bronchi (virology)</term><term>Cell Line</term><term>Cell Polarity</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus (physiology)</term><term>Cytopathogenic Effect, Viral (physiology)</term><term>Epithelial Cells (pathology)</term><term>Epithelial Cells (virology)</term><term>Humans</term><term>SARS Virus (pathogenicity)</term><term>SARS Virus (physiology)</term><term>Species Specificity</term><term>Virus Internalization</term><term>Virus Release (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose</term><term>Bronches (anatomopathologie)</term><term>Bronches (virologie)</term><term>Cellules épithéliales (anatomopathologie)</term><term>Cellules épithéliales (virologie)</term><term>Coronavirus (pathogénicité)</term><term>Coronavirus (physiologie)</term><term>Effet cytopathogène viral (physiologie)</term><term>Humains</term><term>Libération de particules virales (physiologie)</term><term>Lignée cellulaire</term><term>Polarité de la cellule</term><term>Pénétration virale</term><term>Spécificité d'espèce</term><term>Virus du SRAS (pathogénicité)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bronches</term><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bronchi</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term><term>Effet cytopathogène viral</term><term>Libération de particules virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term><term>Cytopathogenic Effect, Viral</term><term>SARS Virus</term><term>Virus Release</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Bronches</term><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchi</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term><term>Cell Line</term><term>Cell Polarity</term><term>Humans</term><term>Species Specificity</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Humains</term><term>Lignée cellulaire</term><term>Polarité de la cellule</term><term>Pénétration virale</term><term>Spécificité d'espèce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><noCountry><name sortKey="Hill, Terence E" sort="Hill, Terence E" uniqKey="Hill T" first="Terence E" last="Hill">Terence E. Hill</name><name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G" last="Ksiazek">Thomas G. Ksiazek</name><name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name><name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J" last="Peters">Clarence J. Peters</name><name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K" last="Tseng">Chien-Te K. Tseng</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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